Deficient Purposeful Use of Forepaws in Female Mice Modelling Rett Syndrome

Figure 3

Spontaneous behavioural profile in the home-cages. The analysis of spontaneous behaviour in the home-cages revealed that MeCP2-308 heterozygous female mice (Het) show decreased cage-directed exploratory behaviours in the home-cages compared to wild-type controls (wt). Burrowing (a) and digging (b) and bar holding episodes (c) were significantly less frequent in Het mice. Het mice spent more time drinking (d) and eating (e) compared to wt. The spontaneous behaviour in home-cages of individually housed mice was scored 3 times per day (11.00-12.00; 14.00-15.00; 18.00-19-00; highlighted by dashed lines in Figure 2). Each session consisted of 15 observations. The profile of daily activity was obtained by averaging 3 consecutive days of data collection. Data are expressed as % frequency ± SEM. .

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