PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury

<div>Immunochemical image for confirmation reduced synaptophysin expression in MCAO mouse brain. Immunochemical images showed that synaptophysin-positive cells (red) were decreased as expressed in MCAO mouse cortex. In addition, immunochemical images showed that MAP2- (considered as the neuron specific microtubule protein) positive cells (green) were strongly decreased in MCAO mouse cortex compared to the normal group. We used 5 rats in each groups for study. Each measurement included 3 repeats per animal. Scale bar = 100 <i>μ</i>m, synaptophysin: red, MAP2: green, 4′, 6-diamidino-2-phenylindole (DAPI): blue, normal: normal control group, and MCAO: reperfusion 24 hr after MCAO injury.</div>

Neural Plasticity

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Figure 1

Figure 1: PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury 

Figure 1 | PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury 