Neuronal BDNF Signaling Is Necessary for the Effects of Treadmill Exercise on Synaptic Stripping of Axotomized Motoneurons

Figure 2

(a) The mean (± SEM) percent coverage by synaptic structures contacting motoneuron somata and proximal-most dendrites is shown for intact wild-type mice and two weeks after transection of the sciatic nerve, in unexercised mice and mice exercised daily, five days per week during that period. Data are shown for synaptic contacts that were immunoreactive for VGLUT1 (white bars) or GAD67 (grey bars). (b) The same data as in (a) are plotted as the mean (±95 confidence interval) percent reduction in synaptic contact, relative to intact mice. for intact, for unexercised, and for exercised.

(a)

(b)