Age-Related Alterations in the Expression of Genes and Synaptic Plasticity Associated with Nitric Oxide Signaling in the Mouse Dorsal Striatum

Figure 6

Age-dependence of alterations in corticostriatal field responses induced by phosphodiesterase (PDE) inhibitors. (a) The mean time course of alterations in corticostriatal field responses in striatal slices from mice of different ages after exposure to the inhibitor of cGMP-specific PDE5 zaprinast (ZPRN, 40 µM, application period is marked by open bar). (b) Initial (averaged through minutes 10–25 after ZPRN, open bars) and long-term (averaged through minutes 60–75 after ZPRN, filled bars) changes in field response amplitudes induced by ZPRN in four age groups ( each). (c) The mean time course of alterations in corticostriatal field responses in striatal slices from mice of different ages after exposure to the inhibitor of cAMP-specific PDE4 rolipram (RLPM, 20 µM, marked by bar). (d) Initial (averaged through minutes 5–20 after RLPM, open bars) and long-lasting (averaged through minutes 55–70 after RLPM, filled bars) changes in field response amplitudes induced by RLPM in four age groups ( = 7–9 per group). In (b) and (d), asterisks indicate significant decline of average response amplitude from the baseline, , , and , paired -test.

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