Research Article
Age-Related Alterations in the Expression of Genes and Synaptic Plasticity Associated with Nitric Oxide Signaling in the Mouse Dorsal Striatum
Table 1
Expression levels of indicated genes involved in synaptic plasticity, oxidative stress, and immunity. mRNA levels are normalized to group I values.
| | Relative mRNA level % | Age groups | | II | III | IV |
| | Synaptic plasticity | | | | | NR1 (Grin1) | 35 ± 8 (7) | 28 ± 5 (4) | 68 ± 3 (4) | | NR 2A | 44 ± 5 (4) | 60 ± 13 (5) | 73 ± 9 (7) | | NR 2B | 61 ± 8 (6) | 96 ± 17 (6) | 79 ± 5 (9) | | NR 2C | 75 ± 12 (4) | 56 ± 7 (4) | 70 ± 10 (8) | | mGluR 1 | 98 ± 8 (4) | 100 ± 15 (4) | 88 ± 11 (6) | | mGluR 5 | 106 ± 8 (4) | 113 ± 9 (4) | 81 ± 16 (6) | | D1R | 81 ± 12 (4) | 88 ± 19 (4) | 44 ± 16 (4) | | D2R | 91 ± 11 (6) | 130 ± 28 (5) | 83 ± 11 (8) | | CB1R | 106 ± 23 (4) | 96 ± 25 (5) | 94 ± 15 (8) | | nNOS | 75 ± 16 (5) | 66 ± 6 (6) | 75 ± 6 (7) | | eNOS | 131 ± 30 (4) | 113 ± 20 (3) | 137 ± 16 (7) | | Oxidative stress | | | | | Txnip | 72 ± 15 (4) | 58 ± 11 (5) | 118 ± 28 (7) | | Cyba | 80 ± 9 (4) | 69 ± 10 (5) | 195 ± 35 (7) | | Gpx6 | 89 ± 15 (6) | 142 ± 24 (6) | 143 ± 17 (8) | | Scd2 | 113 ± 27 (4) | 116 ± 21 (5) | 141 ± 18 (9) | | Immunity | | | | | B2m | 144 ± 12 (4) | 221 ± 63 (5) | 230 ± 30 (9) | | Lcn2 | 122 ± 41 (5) | 215 ± 68 (6) | 474 ± 126 (7) | | Irgm1 | 152 ± 20 (4) | 165 ± 23 (5) | 229 ± 31 (9) |
|
|
Significant differences with this group are indicated by asterisks: , , , one-way ANOVA with Dunnett’s posttest and Mann-Whitney test.
|
