Research Article

Spinal Cord Hemisection Facilitates Aromatic L-Amino Acid Decarboxylase Cells to Produce Serotonin in the Subchronic but Not the Chronic Phase

Table 1

Summary of the results from the different animal groups.

GroupNumber of animalsSpinal cord sideDensity of 5-HT fibers in IMZ1 (% of analyzed area)Density of 5-HT fibers in VH2 (% of analyzed area)Density of AADC cells (number of cells/analyzed section)Density of 5-HT cells (% of AADC cells)

5-day control 5Injured0.89 ± 0.481.19 ± 0.5119.99 ± 3.830
Uninjured3.80 ± 1.225.02 ± 1.2122.37 ± 7.110

5-day 5-HTP + carbidopa 8Injured1.26 ± 0.780.73 ± 0.1819.36 ± 8.7842.52 ± 19.15
Uninjured4.20 ± 1.823.13 ± 0.6115.08 ± 7.6125.86 ± 17.81

60-day control 6Injured0.36 ± 0.060.59 ± 0.388.83 ± 3.450
Uninjured3.24 ± 1.242.72 ± 1.257.10 ± 3.730

60-day 5-HTP + carbidopa 6Injured0.78 ± 0.340.35 ± 0.0811.42 ± 5.9415.98 ± 18.72
Uninjured2.41 ± 1.161.54 ± 0.4610.85 ± 4.809.57 ± 15.00

IMZ: intermediate zone; 2VH: ventral horn.