Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life
Table 3
Comparison of fractional anisotropy (FA) values in each region of interest between healthy newborns and asphyxiated newborns treated with hypothermia developing or not developing brain injury, on day 1 of life, on days 2-3 of life, around day 10 of life, and around day 30 of life.
Thalamus
Posterior limb of internal capsule
Lentiform nucleus
Anterior white matter
Posterior white matter
Frontal cortical grey matter
Parietal cortical grey matter
Occipital cortical grey matter
On day 1 of life
Healthy newborns
0.167 ± 0.006 ()
0.524 ± 0.044 ()
0.136 ± 0.018 ()
0.134 ± 0.031 ()
0.176 ± 0.070 ()
0.153 ± 0.030 ()
0.148 ± 0.022 ()
0.154 ± 0.027 ()
Asphyxiated newborns—no injury
0.169 ± 0.016 ()
0.516 ± 0.049 ()
0.143 ± 0.017 ()
0.113 ± 0.027 ()
0.160 ± 0.035 ()
0.138 ± 0.018 ()
0.139 ± 0.018 ()
0.129 ± 0.031 ()
Asphyxiated newborns—injury
0.174 ± 0.018 ()
0.484 ± 0.031 ()
0.139 ± 0.012 ()
0.101 ± 0.027 ()
0.148 ± 0.020 ()
0.147 ± 0.019 ()
value: no injury versus healthy
ns
ns
ns
ns
ns
ns
ns
ns
value: injury versus healthy
ns
ns
ns
—
—
—
ns
—
value: injury versus no injury
ns
ns
ns
—
—
—
ns
—
On days 2-3 of life
Healthy newborns
0.173 ± 0.012 ()
0.491 ± 0.033 ()
0.143 ± 0.026 ()
0.130 ± 0.018 ()
0.176 ± 0.028 ()
0.162 ± 0.017 ()
0.141 ± 0.038 ()
0.149 ± 0.034 ()
Asphyxiated newborns—no injury
0.165 ± 0.019 ()
0.484 ± 0.038 ()
0.142 ± 0.026 ()
0.128 ± 0.028 ()
0.154 ± 0.025 ()
0.150 ± 0.026 ()
0.146 ± 0.019 ()
0.136 ± 0.029 ()
Asphyxiated newborns—injury
0.173 ± 0.021 ()
0.478 ± 0.041 ()
0.142 ± 0.031 ()
0.128 ± 0.037 ()
0.162 ± 0.035 ()
0.165 ± 0.020 ()
0.139 ± 0.020 ()
0.167 ± 0.029 ()
value: no injury versus healthy
ns
ns
ns
ns
ns
ns
ns
ns
value: injury versus healthy
ns
ns
ns
ns
ns
—
ns
ns
value: injury versus no injury
ns
ns
ns
ns
ns
—
ns
ns
Around day 10 of life
Healthy newborns
0.175 ± 0.011 ()
0.503 ± 0.039 ()
0.156 ± 0.015 ()
0.135 ± 0.017 ()
0.186 ± 0.019 ()
0.159 ± 0.018 ()
0.127 ± 0.020 ()
0.133 ± 0.013 ()
Asphyxiated newborns—no injury
0.171 ± 0.020 ()
0.502 ± 0.040 ()
0.136 ± 0.019 ()
0.131 ± 0.026 ()
0.142 ± 0.031 ()
0.154 ± 0.037 ()
0.140 ± 0.026 ()
0.121 ± 0.026 ()
Asphyxiated newborns—injury
0.153 ± 0.027 ()
0.414 ± 0.040 ()
0.119 ± 0.014 ()
0.112 ± 0.027 ()
0.141 ± 0.025 ()
0.170 ± 0.066 ()
0.145 ± 0.027 ()
0.121 ± 0.020 ()
value: no injury versus healthy
ns
ns
0.009
ns
0.001
ns
ns
ns
value: injury versus healthy
0.048
0.0002
0.001
ns (0.087)
0.0003
ns
ns
ns
value: injury versus no injury
0.021
<0.0001
0.0004
0.034
ns
ns
ns
ns
Around day 30 of life
Healthy newborns
0.197 ± 0.014 ()
0.545 ± 0.028 ()
0.159 ± 0.012 ()
0.160 ± 0.016 ()
0.229 ± 0.042 ()
0.182 ± 0.047 ()
0.169 ± 0.027 ()
0.132 ± 0.019 ()
Asphyxiated newborns—no injury
0.195 ± 0.024 ()
0.543 ± 0.047 ()
0.154 ± 0.022 ()
0.142 ± 0.028 ()
0.186 ± 0.052 ()
0.154 ± 0.026 ()
0.160 ± 0.027 ()
0.139 ± 0.040 ()
Asphyxiated newborns—injury
0.173 ± 0.017 ()
0.474 ± 0.040 ()
0.145 ± 0.015 ()
0.115 ± 0.027 ()
0.153 ± 0.042 ()
0.180 ± 0.041 ()
0.173 ± 0.014 ()
0.169 ± 0.049 ()
value: no injury versus healthy
ns
ns
ns
ns (0.074)
0.025
ns
ns
ns
value: injury versus healthy
0.003
0.0001
0.022
0.004
0.0006
—
ns
—
value: injury versus no injury
0.002
<0.0001
ns
0.011
ns
—
ns
—
Mean ± standard deviation Injury versus no injury: , , and .
