Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity

Figure 5

DA modulates GABAergic synaptic plasticity of MSNs. (a and g) are representative IPSC traces in the presence of DA (200 nM or 20 μM, resp.) before (top) and after HFS (middle) and an overlap of the recordings (bottom). (b) Time course of the IPSC amplitude before and after HFS in the presence of DA 200 nM (light blue) and 20 μM (dark blue). (c and h) show the distribution, in percentages, of the types of plasticity that were generated in the presence of DA (200 nM or 20 μM, resp.). (d and i) are the PPR comparisons of the IPSCs before and after HFS in the presence of DA (200 nM or 20 μM). (e and j) are the rise time, while (f and k) are the decay time before and after HFS in the presence of DA (200 nM or 20 μM).