Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol

Table 1

Dopaminergic regulation of striatal interneurons.

Neuron type	Subregion	Manipulation	Effect on firing rate	Reference
FSI	nAc	Nicotine + dopamine receptor antagonist/in vivo	↓	[109]
FSI	nAc	Cocaine withdrawal	↑	[111]
FSI	Striatum	Amphetamine/in vivo	↑	[108]
FSI	Striatum	Dopamine in D1KO via D5R	↑	[100]
FSI	Striatum	Dopamine, cocaine, via D1R activation	↑	[110]
FSI	Striatum	D2R activation	↓	[100, 108]
FSI	Striatum	Impaired nigrostriatal connectivity	↓	[112, 113]
LTS	Striatum	Dopamine via D1-type R	↑	[98]
Cholinergic interneurons	nAc	Optogenetic activation of dopamine neurons	↑	[128, 129]
Cholinergic interneurons	Striatum	Optogenetic activation of dopamine neurons	↓	[128, 130]
Cholinergic interneurons	Striatum	D2R activation	↓	[100]
Cholinergic interneurons	Striatum	Dopamine depletion	↑	[113]