Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus

Figure 5

Effect of inhibition of NEU activity on the long-term potentiation and the short-term depression in hippocampal CA3-to-CA1 network induced by 50 Hz stimulus train. (a) Average of baseline-normalized initial slopes of fEPSP evoked by stimulation of Shaffer collateral before and after delivery of 50 Hz train in control (white) and NADNA-pretreated slices (grey). (b) Cumulative changes in field potentials recorded during 50 Hz stimulation in control (white) and NADNA-pretreated slices (grey). fEPSP slopes were normalized to the fEPSP slope in response to the first pulse and graphed versus pulse number. Inset: field potential recording during 50 Hz HFS.

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