Research Article

Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus

Figure 6

Synaptic depotentiation restores LTP in NADNA-pretreated slices to the control level. Pretreatment of slices with NADNA did not affect LTD of fEPSP evoked by LFS stimulation. Thirty min after the induction of LTD, tetanic stimulation of the Shaffer collaterals induces a similar potentiation of the field potential responses in NADNA-pretreated and control slices. All data are presented as Mean ± SE.