Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca²⁺-Dependent Mechanisms

Figure 4

Effects of 50 mg/L cordycepin on amplitude and conductive velocity of compound nerve action potential (CNAP) in RS supplemented with 0.4 mM CdCl₂ or 0.15 mM LaCl₃. (a) Sample traces (top) show the CNAP recorded before, during, and after cordycepin was applied in RS + CdCl₂ medium. Below are the time courses of the effects of cordycepin on the amplitude of CNAP conduction. Horizontal bar indicates the bath application of cordycepin. (b) Summary of changes in conductive velocity of CNAP induced by cordycepin. The velocity of the stable state before the nerve was exposed to cordycepin is defined as the control value and scaled to 100%.

(a)

(b)