CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation

Figure 6

CRMP2 and CRMP4 interact with the cytoskeleton to promote growth cone development and axonal elongation. (a) Representative images of growth cones from neurons transfected with CRMP4 alone or together with CRMP2ΔC322 or with CRMP2 alone or together with CRMP4ΔC472 are shown. Scale bar: 10 μm. The relative ratio of the growth cone area was measured and is shown in the right panel. Mean ± SEM, ; versus vector control; versus indicated group. (b) Representative images of GFP staining from hippocampal neurons with the same transfection as in (a) are shown. Axon length was measured as the mean ± SEM from three independent experiments. versus vector control; versus vector control; versus indicated group. Scale bar: 100 μm.

(a)

(b)