P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction

<div>Modulation of excitatory synaptic transmission by P2Y receptors in the CNS. The model synapse shows the main presynaptic and postsynaptic effects of P2Y receptors described in different areas of the brain. For more details see text. AMPAR, AMPA receptor; GIRK, G protein-coupled inwardly rectifying potassium channel; Glu, glutamate; K<sub>Ca</sub>, calcium-activated potassium channel; LTD, long-term depression; NMDAR, NMDA receptor, P2YR, P2Y receptor; P2Y<sub>1</sub>R, P2Y<sub>1</sub> receptor; TRP, transient receptor potential channel; VACC, voltage-activated calcium channel.</div>

Neural Plasticity

fig1

Figure 1

Figure 1: P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction 