Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats

Figure 1

Microphotographs of the rat mPFC cortex showing PSA-NCAM immunostaining in control (a, c) and Endo-N treated rats (b, d). Pictures (a) and (b) show the dorsal (Cg1) and ventral cingulate cortices (Cg2) and pictures (c) and (d) show the infralimbic (IL) and prelimbic (PrL) cortices. Note in (b) the lack of PSA-NCAM expression in Cg1 and Cg2 (as observed in (d) for IL and PrL), but not in the striatum, demonstrating the effectiveness of Endo-N treatment. Roman numbers indicate cortical layers. Scale bar: 100 μm. Stereotaxic coordinates: Bregma +1.80 mm, Interaural 10.80 mm for figures (a) and (b); Bregma +3.00 mm, Interaural +12.00 mm for figures (c) and (d) [14].

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