Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats

Figure 4

Dendritic spine density in mPFC pyramidal neurons after PPHT or Endo-N treatment and their combination. (a) Graph showing statistically significant differences between groups ( animals/group) when considering the total length (200 μm) of the measured dendrites. (b) Camera lucida drawings of 50 μm length dendritic segments located 150–200 μm distal from the soma in dorsal cingulate cortex (Cg1), layer III. Note the decreased number of dendritic spines in all treated groups when compared with Control/Control group. (c) Graph representing dendritic spine density as a function of distance from the soma in 50 μm length segments ( animals/group). Error bars represent SEM and symbols in bars indicate statistically significant differences between groups (see graph legend) after one-way ANOVA followed by Bonferroni’s correction. For graph (a), , , and . For graph (c), please see values in Results.

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