Value of Functionalized Superparamagnetic Iron Oxide Nanoparticles in the Diagnosis and Treatment of Acute Temporal Lobe Epilepsy on MRI

Figure 1

MR images of rat brains in the three groups are shown before and after tail vein injection of particles (15 mg/kg). ((a), (c), and (e)) Baseline MRI prior to injection with saline, P-SPIONs, anti-IL-1β, and mAb-SPIONs; (b) MR images acquired 4 h after saline injection. (d) MR image acquired 4 h after P-SPIONs injection; area of negligible negative enhancement is not visible (red arrow). (f) MR images acquired 4 h after anti-IL-1β mAb-SPIONs injection; area of negative enhancement is visible (red arrow) in CA3 showing unilateral uptake of particles; (g) the changes in the value of T2 before and after injection in the three groups. Data represent mean ± SD of 10 pilocarpine-SE rats per group. versus preinjection. between three groups when preinjected.

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