Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals

Figure 1

Volcano plot of methylation differences of all the CpG sites associated with microRNA genes. In total, 161 CpG sites were found to be differentially methylated () in Alzheimer’s disease (AD) group compared to controls, most of them hypermethylated; the 10 miRNA CpG sites highlighted in red map to transcripts previously reported as dysregulated in AD brains.