Spindle Bursts in Neonatal Rat Cerebral Cortex

Figure 5

Movement-correlated synchrony of spontaneous network activity in S1 and primary motor cortex (M1) in newborn rat in vivo. (a) Schematic illustration of the experimental setup with multielectrode arrays in S1 (red) and M1 (blue). Piezo element attached to the contralateral forepaw monitors movements. Blue line indicates the motor pathway and red line the sensory pathway. (b) Relationship between forepaw movements and cortical activity in S1 and M1 in a P4 rat. (A) Spontaneous activity in M1 (black) elicited forepaw movement and preceded spindle burst in S1 (red). Black dashed line indicates time point of forepaw movement. Top black trace shows forepaw movement. (B) Spontaneous forepaw movement preceded activity in M1 (green) and spindle burst in S1 (red). (c) Relationship between spontaneous activity in M1 and S1 and forepaw movements. (A) Bar diagram illustrating the occurrence of FP activity, which preceded forepaw movements (blank box), followed forepaw movements (green), and were unrelated to movement (blue) in 16 P3–P5 rats. Red bars represent results from the shuffled dataset. (B) Pie diagram showing the percentages of the three patterns (1708 events from 16 P3–P5 rats during 10 min unstimulated recordings). (C) Cross-correlation of MUA between S1 and M1. Note that S1 MUA precedes M1 MUA (green arrowhead) and M1 MUA precedes S1 MUA (blank arrowhead). Yellow traces represent results from the shuffled dataset. Reproduced with permission from [19].

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