A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

Figure 3

Cerebral blood flow (CBF) as measured with a flow-sensitive MRI technique (FAIR ASL) at 12 months and 18 months of age in C57BL/6J wild-type control mice and ApoE4 transgenic mice on control diet or Fortasyn diet. Three regions of interest (ROIs) on the left and right brain hemispheres were analysed: cortex, hippocampus, and thalamus. (a) In the 12-month-old mice we detected a genotype × diet interaction in the thalamus (). Fortasyn diet increased thalamic CBF () more strongly in wild-type mice than in the apoE4 littermates. (b) In the 18-month-old mice, CBF was decreased in the cortex () and in the thalamus () of apoE4 mice as compared to wild-type mice. Cortical CBF was increased by the Fortasyn diet in both wild-type and apoE4 mice (). ; ; .

(a)

(b)