A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

Figure 7

Levels of postsynaptic density-95 (PSD-95) in various brain areas in wild-type mice and apoE4 mice on either control diet or Fortasyn diet. (a) At 12 months, we did not find significant differences between groups. (b) At 18 months, reduced PSD-95 levels were seen in the sensory cortex of apoE4 mice compared to wild-type mice (). Fortasyn diet increased levels of PSD-95 in the sensory cortex (), CA3 area (), and IML (), irrespective of genotype. No genotype × diet interactions were observed. ; ; .

(a)

(b)