A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD

Table 7

Results from the subgroup analyses with and without Zhang et al. (2014) [27] and Dretsch et al. (2016) [29] from the random-effects model.

Analysis	Model	Odds ratio	95% CI		Fail Safe
Ethnicity
Caucasian	Val/Val versus Val/Met	1.14	0.84; 1.55	N/A	0.71
	Val/Val versus Met/Met	1.72	0.00;	98.46	3.60
	Recessive	0.92	0.84;	N/A	N/A
	Dominant	0.73	0.26; 2.09	48.90	N/A
	Allele	0.96	0.73; 1.27	35.96	N/A
Asian	Val/Val versus Val/Met	0.80	0.57; 1.11	N/A	N/A
	Val/Val versus Met/Met	0.67	0.20; 2.19	83.90	N/A
	Recessive	0.79	0.54; 1.16	21.58	N/A
	Dominant	1.34	0.53; 3.39	80.38	1.71
	Allele	1.20	0.70; 2.08	82.22	1.04
PTSD−	Val/Val versus Val/Met	0.86	0.40; 1.84	89.50	N/A
	Val/Val versus Met/Met	0.61	0.09; 4.00	95.33	N/A
	Recessive	0.70	0.30; 1.68	93.48	N/A
	Dominant	0.96	0.009; 10.65	97.09	N/A
	Allele	1.44	0.55; 3.78	96.91	2.64
PTSD−; Zhang et al. (2014) [27] removed	Val/Val versus Val/Met	0.95	0.54; 1.68	69.17	N/A
	Val/Val versus Met/Met	0.66	0.18; 2.55	88.64	N/A
	Recessive	0.85	0.65; 1.10	22.69	N/A
	Dominant	0.71	0.04; 11.63	97.19	N/A
	Allele	1.24	0.83; 1.83	76.44	1.41
PTSD−; Zhang et al. (2014) [27] and Dretsch et al. (2016) [29] removed	Val/Val versus Val/Met	0.84	0.66;	6.22	N/A
	Val/Val versus Met/Met	0.85	0.26; 2.80	84.52	N/A
	Recessive	0.82	0.60; 1.15	42.00	N/A
	Dominant	0.57	0.03; 11.16	97.59	N/A
	Allele	1.21	0.77; 1.91	80.97	1.06

Note. Approaching significance; very wide confidence intervals potentially due to frequencies.