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# | Stress | Paradigms | Animals | CA1 | CA3 | References |
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1 | CRS | 6 h/day for 21 days | Male SD rats | nd | Apical, not basal dendritic atrophy | [28] |
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2 | CRS | 6 h/day for 21 days | Male SD rats | nd | ↑ spine density in apical, basal dendrites | [29] |
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3 | CRS or multiple stress (CMS): 3 different stressors | CRS, 6 h/day for 21 days CMS: 3 stressors/day for 21 days | Male SD rats | nd | Apical dendritic atrophy; CORT habituates to 21-day CRS but not 21-day CMS | [30] |
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4 | CRS | 6 h/day for 21 days | Male SD rats | nd | Apical dendritic atrophy is blocked by cyanoketone or CGP43487 | [31] |
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5 | CRS | 6 h/day for 21 days |
Male SD rats | nd | ↑ synaptic vesicle density in MFT | [32] |
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6 | CRS | 6 h/day for 21 days | Male SD rats | nd | Apical dendritic atrophy, recovery after 10 days ↓ spine density | [33] |
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7 | CRS | 6 h/day for 21 days | Adult male Wister rats | nd | ↑ excitatory MF-CA3 synapses, recovery after maze learning | [34] |
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8 | Acute restraint plus intermittent tail shock | 30 shocks: 1 mA, 1 s, 1/min | Adult male and female SD rats | ↑ spine density in male and ↓ in female apical dendrites, both 100% blocked by CPP | nd | [35] |
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9 | CRS | 6 h/day for 21 days | Male Wistar rats | nd | ↓ PSD number; ↓ spine density in apical dendrites Retraction of dendritic TE with ↓ in their volume | [36] |
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10 | CRS | 6 h/day for 21 days | Adult SD adult female rats | ↔ dendritic atrophy ↑ spine density ↑ spine size | Apical dendritic atrophy Spine density, nd | [37, 38] |
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11 | CRS | 6 h/day for 21 days | Male Wistar rats | ↑ PSD surface and ↑ PSD volume; ↔ excitatory synapses in stratum | nd | [39] |
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12 | CRS | 6 h/day for 21 days | C57/BL6 male Wt mice | ↓ spine density in apical dendrite ↓ NR1, NR2B, NR2A, and GAP43 | These decreases are tPA and plasminogen dependent | [40] |
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13 | CRS | 6 h/day for 21 days | C57/BL6 male Wt mice | ↔ dendritic atrophy; ↓ total spine density, ↔ stubby spines ↓ thin and mushroom spine density | Apical, not basal dendritic atrophy ↔ total spine density, ↑ stubby spines, ↓ thin and mushroom spines | [41] |
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14 | CRS | 6 h/day for 21 days | Adult SD female rats | ↔ dendritic atrophy ↑ spine density ↑ mushroom spine | Apical dendritic atrophy ↓ spine density | [42] |
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15 | CRS | 2.5 h/day for 14 days | Male rats | ↓ spine density in apical dendrites | nd | [43] |
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16 | CRS | 6 h/day for 21 days | Adult SD male rats | ↑ spine density | Apical dendritic atrophy, ↓ spine density, and ↑ spinophilin and Homer1 | [44] |
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17 | CRS | 6 h/day for 21 days | Female mice | ↓ spine density in apical dendrites | nd | [45] |
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18 | CRS | 2.5 h/day for 14 days | Adult male SD rats | ↓ spine density, ↓ cadherin, and ↔ LIMK/cofilin and p-LIMK/p-cofilin | nd | [46] |
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19 | CRS | 6 h/day for 25 days | Female, male Long-Evans rats | ↓ spine density in basilar dendrites; ↑ apical dendritic arbors in female, not male ventral CA1 | Deficits in spatial memory in female but not male | [47] |
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20 | CRS | 6 h/day for 21 days | Adult male mice | ↓ spine density; ↓ p-Akt, ↓ p-GSK-3β, and ↓ p-Erk1/2 | nd | [48] |
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21 | CUMS | 1 stressor/day for 30 days | Male Wister rats | ↔ apical dendrite | Apical dendritic atrophy; ↓ MF-CA3 synapses | [49] |
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22 | CUMS | 2 stressors/day for 10 days | Male Wister rats | nd | ↔ CA3 dendrites | [50] |
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23 | CUMS | 1 stressor/day for 21 days | Male SD rats | ↓ CA1 spine density | ↓ CA3 spine density, ↓ Kalirin-7 protein in hippocampus | [24] |
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24 | CUMS | 1 stressor/day for 14 days | Male mice | nd | ↑ CA3 spine density | [51] |
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25 | CUMS | 1 stressor/day for 8 weeks | Male SD rat | ↓ PSD thickness in CA1 ↓ PSD95 protein | ↓ PSD93, ↓ PSD95, ↓ SYN, ↓ spinophilin, and ↓ synapsin 1 | [52] |
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26 | CUMS | 2-3 stressors/day for 21–35 days | Adult SD rats | Impaired AMPAR-synaptic excitation at TA-CA1 synapses ↓ GluR1 and PSD95 | Induces depression-like behaviors | [53] |
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27 | CUMS | 2 stressors/day for 28 days | Male C57/b mice | ↓ mGlu2 receptors in susceptible, not resilient mice | mGLu2 deletion in mice results in a more severe susceptibility to stress | [54] |
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28 | Multimodal stress | Adult male C57BL/6J mice | 5 h | ↓ synapse numbers in dorsal apical dendrites ↓ PSD-95-ir puncta | ↓ synapse numbers in dorsal CA3 apical ↓ PSD-95-ir puncta | [55] |
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29 | Psychosocial stress | 1 h/day for 28 days | Male tree shrews | nd | Apical, not basal dendritic atrophy ↔ spine density | [56] |
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30 | Psychosocial stress | 1 h/day for 28 days | Male rats | nd | Apical dendritic atrophy | [57] |
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31 | Chronic CORT exposure | 3-4 weeks | Male SD rats | Impaired AMPAR-synaptic excitation at TA-CA1 synapses ↓ GluR1 protein | Induces depression-like behaviors | [58] |
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32 | CORT exposure | 35 days | C57/BL6 male mice | ↓ CA1 thin and stubby spine density, but not mushroom spines | ↔ CA3 spine density | [59] |
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