K_V1 and K_V3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat

Figure 1

Nonspecific potassium blockers reveal the presence of presynaptic potassium channels at corticostriatal synapses. (a) Exposure to 4-AP (1 mM) causes an increase in the amplitude of the first synaptic response decreasing PPF. Representative traces recorded from the same slice before (upper trace) and after (lower trace) exposure to 4-AP are shown. (c) A similar effect was observed when applying TEA (1 mM). In both cases, paired-pulse facilitation reduction was dependent of the concentration used. (d) and (b), Dose-response relation for TEA and 4-AP, respectively.

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