K<sub>V</sub>1 and K<sub>V</sub>3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat

<div><svg height="11.6151pt" id="M96" style="vertical-align:-3.227119pt" version="1.1" viewbox="-0.0498162 -8.38798 15.9287 11.6151" width="15.9287pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M667 0V28C619 34 599 43 546 100C496 154 386 277 311 372C378 440 449 512 488 547C551 605 575 615 650 622V650H410V622L433 619C478 614 479 604 449 568C404 513 337 443 282 390C254 364 234 350 212 345V520C212 609 222 616 299 622V650H41V622C120 616 128 611 128 520V128C128 41 120 34 44 28V0H304V28C221 34 212 41 212 128V318C229 321 242 318 266 291C355 185 436 87 514 0H667Z" id="g121-73"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="673" vert-adv-y="673"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.749,3.132)"><path d="M698 650H468V617C551 609 555 599 536 543C506 457 432 264 379 129H377C311 297 238 488 212 560C196 604 198 609 271 617V650H21V617C80 612 98 603 127 532C183 396 268 173 335 -9H370C445 196 551 450 578 511C615 602 630 609 698 617V650Z" id="g58-84"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="717" vert-adv-y="717"></glyph.data></g></svg>3.4 channel blockers reduced PPR. The presence of <svg height="11.6151pt" id="M97" style="vertical-align:-3.227119pt" version="1.1" viewbox="-0.0498162 -8.38798 15.9287 11.6151" width="15.9287pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M667 0V28C619 34 599 43 546 100C496 154 386 277 311 372C378 440 449 512 488 547C551 605 575 615 650 622V650H410V622L433 619C478 614 479 604 449 568C404 513 337 443 282 390C254 364 234 350 212 345V520C212 609 222 616 299 622V650H41V622C120 616 128 611 128 520V128C128 41 120 34 44 28V0H304V28C221 34 212 41 212 128V318C229 321 242 318 266 291C355 185 436 87 514 0H667Z" id="g121-73"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="673" vert-adv-y="673"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.749,3.132)"><path d="M698 650H468V617C551 609 555 599 536 543C506 457 432 264 379 129H377C311 297 238 488 212 560C196 604 198 609 271 617V650H21V617C80 612 98 603 127 532C183 396 268 173 335 -9H370C445 196 551 450 578 511C615 602 630 609 698 617V650Z" id="g58-84"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="717" vert-adv-y="717"></glyph.data></g></svg>3.4 channels was revealed blocking corticostriatal synapse with BDS-1 (47 nM). Left superior panel shows time course of PPR of the experiment, and left bottom shows the time course of amplitudes of both <svg height="11.8174pt" id="M98" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -8.6359 11.1398 11.8174" width="11.1398pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M449 634C442 637 425 643 405 650C376 660 341 666 307 666C181 666 98 590 98 485C98 400 170 343 215 310L246 288C307 243 343 204 343 147C343 67 291 18 219 18C104 18 61 124 51 202L23 199C28 124 27 71 27 47C47 22 122 -16 204 -16C324 -16 428 60 428 174C428 256 379 309 307 360L276 382C223 419 179 455 179 516C179 576 221 632 293 632C379 632 410 564 418 487L448 490C446 536 446 592 449 634Z" id="g113-84"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="472" vert-adv-y="472"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,6.071,3.132)"><path d="M389 0V32C297 38 291 46 291 118V635C234 613 175 595 109 583V556L161 554C203 552 207 547 207 497V118C207 46 201 38 110 32V0H389Z" id="g50-50"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg> and <svg height="11.8174pt" id="M99" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -8.6359 11.1398 11.8174" width="11.1398pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M449 634C442 637 425 643 405 650C376 660 341 666 307 666C181 666 98 590 98 485C98 400 170 343 215 310L246 288C307 243 343 204 343 147C343 67 291 18 219 18C104 18 61 124 51 202L23 199C28 124 27 71 27 47C47 22 122 -16 204 -16C324 -16 428 60 428 174C428 256 379 309 307 360L276 382C223 419 179 455 179 516C179 576 221 632 293 632C379 632 410 564 418 487L448 490C446 536 446 592 449 634Z" id="g113-84"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="472" vert-adv-y="472"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,6.071,3.132)"><path d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z" id="g50-51"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg> synaptic response. Right panel shows representative recordings indicated in left panel.</div>

Neural Plasticity

fig3

Figure 3

Figure 3: K<sub>V</sub>1 and K<sub>V</sub>3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat 

Neural Plasticity

KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat

Figure 3

K_V1 and K_V3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat