Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition

<div>Model. Ribosome biogenesis in Alzheimer’s disease. (a) Normal neuron. PARP-1 activity (PAR) prevents rDNA methylation. PAR = poly(ADPribosyl)ation. (b) AD neuron. Absence of PARP-1 in nucleoli allows DNA methyltransferase (Dnmt1) to methylate rDNA promoters silencing rRNA transcription resulting in nucleolar disruption.</div>

Neural Plasticity

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Figure 4: Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition 