Research Article
mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits
Figure 4
The expression of Arc and the ratio of GluA1/GluA2 surface expression are altered by cocaine history and intra-dlSTR administration of MTEP. (a) Arc expression was significantly increased by cocaine and this effect was prevented in rats that were treated with intra-dlSTR MTEP prior to the relapse test. (b) The ratio of GluA1/GluA2 was reduced significantly in Veh-treated cocaine rats relative to Veh-treated Sal control rats. compared to Sal-Veh. compared to Veh-Coc.
(a) |
(b) |