mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits

Table 1

Immunoreactivity of mGlu5-interacting proteins in the dlSTR 22 hr after the context-induced relapse test.

Protein	Treatment group
	Sal-Veh	Sal-MTEP	Coc-Veh	Coc-MTEP
CAMK II	0.724 ± 0.093	0.883 ± 0.058	0.840 ± 0.095	0.723 ± 0.067
Dynamin II/III	0.815 ± 0.095	0.830 ± 0.101	0.918 ± 0.068	0.780 ± 0.071
GRK2	0.553 ± 0.046	0.460 ± 0.068	0.629 ± 0.068	0.702 ± 0.058
Homer 1b/c	0.404 ± 0.044	0.413 ± 0.050	0.450 ± 0.051	0.374 ± 0.041
Homer 2a/b	1.347 ± 0.141	1.500 ± 0.117	1.562 ± 0.184	1.372 ± 0.144

All data were normalized to calnexin control (within sample) and to the Sal-Veh control (between groups). Data represent mean immunoreactivity ± SEM ( = 5–9). compared to Sal.