Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome

Figure 2

Potential patterns linking mGluRs theory and GABA theory which influence synaptic plasticity involving proteins regulated by FMRP. Activation of Gp1 mGluRs enables the mobilization of endocannabinoids (eCB) in the postsynaptic neuron and retrogradely modulates GABA release through a mechanism known as depolarization-induced suppression of inhibition (DSI). In the whole process, Ca²⁺ influx into postsynaptic neuron participates in the mobilization of endocannabinoids, whereas at presynaptic neuron, Ca²⁺ influx into the cytoplasm restrained by endocannabinoids participates in the inhibition of GABA release.