Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome

Table 2

FMRP selectively regulates signaling pathways associated with transcript targets in different brain regions.

Brain areas	Synaptic plasticity phenotypes	Signaling pathways
Hippocampus	mGluR-LTD	ERK1,2 [49]; mTOR phosphorylation [49]; CB1 signaling [50]
	LTP deficits	PKC-CaMKII [51]; Ras-PI3K/PKB [52]
	Increased STP	Decreased presynaptic BKCa^2+ channels activity [53]
Amygdala	LTP deficits	cAMP-CREB [28, 54]
ACC	Decreased LTP	CaMKIV [55]
PFC	Impaired LTP	Gαs-cAMP [56]