CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory

Table 1

Changes in memory of cannabinoid receptor KO mice. Changes in various types of memory of CB1R KO and CB2R KO mice, compared with WT mice, are summarized from our current results and other studies. Spatial working memory was assayed in a spontaneous alternation test in a Y-maze. Spatial reference memory was measured in a Morris water maze. ↑: enhanced; ↓: impaired; =: unaffected.

	CB2R KO		CB1R KO
Spatial
Working	↑	Figure 2(b)	↓	[43]
Reference			Acquisition =; Extinction ↓	[44, 45]
Conditioned fear
Contextual	↓	Figure 1(b)	↓; ↑	[46]; [47]
Cued	=	Figure 1(c)	Acquisition =; Extinction ↓	[48]
Passive avoidance	↓	[27, 34]	=	[49]