A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways

<div>Multiple attractive and repulsive molecular cues, including guidance cues (netrins, ephrins, semaphorins, slit, neurotrophic factors, and morphogens.) and neural cell adhesion molecules (L1, L2/HNK-1), act on the growth cone and change the motility of it through multiple signaling pathways. The membrane protrusion of growth cone is responsible for attractive response towards molecular cues, while the collapse of growth cone is held accountable for repulsive response towards molecular cues.</div>

Neural Plasticity

fig1

Figure 1

Figure 1: A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways 

Figure 1 | A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways 