Ketamine Administration Reverses Corticosterone-Induced Alterations in Excitatory and Inhibitory Transmission in the Rat Dorsal Raphe Nucleus

Figure 2

Single ketamine injection reverses the effect of repeated corticosterone administration on DRN glutamatergic transmission. (a) Sample recordings from representative neurons in slices prepared from animals treated with Tween+NaCl (upper left trace), Tween+Ket (lower left trace), Cort+NaCl (upper right trace), and Cort+Ket (lower right trace). (b₁) Cumulative probability plots of interevent intervals of sEPSCs recorded from individual representative neurons from all four groups of rats. (b₂) Cumulative probability plots of amplitudes of sEPSCs recorded from individual representative neurons. (c₁) Summary graph showing the mean frequency (±SEM) of sEPSCs recorded from all neurons from the Tween+NaCl-, Tween+Ket-, Cort+NaCl-, and Cort+Ket-treated rats. . (c₂) Mean amplitudes (±SEM) of sEPSCs recorded from all neurons divided into the four investigated groups of animals (labels as in (c₁)).