Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment

Figure 2

The average size of PARP-1 positive nucleoli is reduced in MCI in CA2 and CA4. (a) The average diameter of H&E stained nucleoli in CA1-CA4 shows no significant differences among Control, MCI and AD groups. (b) The average diameter of the subset of nucleoli positive for PARP-1 staining is smaller in CA2 neurons in MCI compared to Control and AD, while PARP-1 positive CA4 nucleoli are smaller in MCI than Control and differences between MCI and AD do not reach significance. Size of PARP-1 positive nucleoli in CA1 and CA3 are not different between groups. denotes . denotes .

(a)

(b)