Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment

Table 1

Demographic and diagnosis data for study cases.

Case #	Sex	Diagnosis	PARP-1 proportion	Nucleolar diameter	PARP-1 positive Nucleolar diameter	Age	Braak score
1	F	Control	✓	✓	✓	95	III
2	M	Control	✓	✓	✓	93	I
3	F	Control	✓	✓	✓	84	III
4	M	Control	✓	✓	✓	86	I
5	M	Control	✓		✓	71	II
6	M	Control	✓		✓	72	I
7	M	Control		✓		69	I
8	M	Control		✓		72	0
9	M	Control		✓		71	II
10	F	Control		✓		81	II
11	M	Control		✓		97	II
12	F	Control		✓		87	II
13	M	Control		✓		85	IV
14	M	MCI	✓	✓	✓	82	III
15	M	MCI	✓	✓	✓	97	III
16	F	MCI	✓	✓	✓	78	IV
17	F	MCI	✓		✓	90	IV
18	M	MCI	✓		✓	96	IV
19	F	MCI	✓		✓	93	IV
20	M	AD	✓	✓	✓	86	VI
21	M	AD	✓	✓	✓	90	V
22	M	AD	✓	✓	✓	76	V
23	F	AD	✓		✓	88	V
24	M	AD		✓		89	IV-V
		Control	6	11	6	81.8	1.8
Summary data		MCI	6	3	6	89.3	3.7
		AD	4	4	4	85.8	5.1