Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer’s Disease

Figure 5

Heat maps showing the mean phase-amplitude coupling (PAC) between contralateral CA1L and ipsilateral CA1R electrodes for buffer- (left heat maps in each frame) and K18- (right heat maps in each frame) injected animals at recording week 1 (buffer , K18 ). (a) represents the strength of PAC between theta oscillations (phase) from CA1L and gamma oscillations (amplitude) at CA1R, while (b) represents the strength of PAC between theta oscillations from CA1R and gamma oscillations at CA1L. Bar charts quantifying the mean PAC between the stated electrodes (shown with 95% CI) for buffer- (black) and K18- (green) injected animals. These mean PAC values are calculated as the average PAC for the window of phase frequency: 3.5–11 Hz, and amplitude frequency: 32–100 Hz, to focus on theta-gamma PAC. Horizontal lines above the bar plots with asterisks indicate the presence of significant difference between buffer- and K18-injected animals (two-sample -test; and ).

(a)

(b)