Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer’s Disease

Figure 6

(a) Graphs showing the mean (across animals) global coherence efficiency (with 95% CI) for buffer-injected (black) and K18-injected (green) mice, at week 1 (buffer , K18 ). Horizontal lines above bar plots with asterisks indicate the presence of significant difference between buffer- and K18-injected animals (two-sample -test: ). (b) The top line graph shows the mean (across animals) coherence values (with 95% CI) between CA1L and CA1R electrodes for buffer-injected (black) and K18-injected (green) mice, at week 10 for the frequency range 0-100 Hz. On the right-hand side, bar charts show the mean (across animals) coherence (with 95% CI) for both groups for the frequency range of interest. Bottom line graphs show the mean (across animals) partial coherence values (with 95% CI) between the same electrodes. On the right-hand side, bar charts show the mean partial coherence (with 95% CI) for both groups for the same frequency range, 0-100 Hz. Horizontal lines above bar plots with asterisks indicate the presence of significant difference between buffer- and K18-injected animals (two-sample -test; ). (c) Graphs showing the mean (across animals) extended partial directed coherence (with 95% CI) from CA1R to CA1L and (d) CA1L to CA1R for buffer-injected (black) and K18-injected (green) mice, at recording week 10. On the left-hand side, these data are presented in the form of a line graph, showing mean (across animal) extended partial directed coherence as a function of frequency (with 95% CI) for both groups for the frequency range 0-100 Hz. On the right-hand side, bar charts show the mean (across animals) extended partial directed coherence (with 95% CI) for both groups for frequency ranges 30-50 and 50-100 Hz. Horizontal lines above the bar plots with asterisks indicate the presence of significant difference between buffer- and K18-injected animals (two-sample -test; and ).

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