Research Article
iTRAQ-Based Protein Profiling in CUMS Rats Provides Insights into Hippocampal Ribosome Lesion and Ras Protein Changes Underlying Synaptic Plasticity in Depression
Figure 1
The CUMS paradigm causes depressive behaviors and hippocampal pathology. (a) Timeline of the CUMS paradigm and behavioral assessments. (b–e) CUMS causes depressive behaviors such as weight loss, anxiety, and anhedonia ( rats/group). (f and g) Hippocampus lesion caused by CUMS shown in CA1 H&E staining ( rats/group). Scale bars: 20 μm. Bar graphs: . vs. control. Student’s t-test.
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