Research Article

iTRAQ-Based Protein Profiling in CUMS Rats Provides Insights into Hippocampal Ribosome Lesion and Ras Protein Changes Underlying Synaptic Plasticity in Depression

Table 1

Differentially expressed proteins between the CUMS and control groups.

Uniprot accessionProtein nameGeneFold change (CUMS/control)

F1LZP5Protein Tgm7Tgm7l1Undetected in control group/
G3V7Q3Coiled-coil domain-containing protein 127Ccdc127Undetected in control group/
Q5YB86Itch E3 ubiquitin ligaseItchUndetected in control group/
B4F797RGD1311345 protein (fragment)RGD1311345Undetected in control group/
G3V6E7FibromodulinFmodUndetected in control group/
Q8VHJ9Nesprin-1Syne1Undetected in control group/
P04177Tyrosine 3-monooxygenaseThUndetected in control group/
P106881-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1Plcd1Undetected in control group/
D3ZJB8Ariadne homolog 2 (Drosophila) (predicted), isoform CRA_aArih22.150.04
Q9R1B1Mitochondrial import inner membrane translocase subunit Tim10 BTimm10b2.050.01
D3ZEK6Protein Gipc3Gipc31.970.04
D3ZBE8Protein Upf3bUpf3b1.960.01
Q2MCP5Protein Wdr45bWdr45b1.880.01
P61023Calcineurin B homologous protein 1Chp11.860.001
D3ZJ32Protein Esyt2Esyt21.610.02
Q08851Syntaxin-5Stx51.560.01
D4A634Protein Ranbp6Ranbp61.370.03
A0A0G2K132Protein Fmnl2Fmnl21.370.01
D3ZZU4Protein Tmem160Tmem1601.350.05
Q568Z4Signal peptidase complex subunit 3Spcs31.340.02
Q99PJ4Diphosphomevalonate decarboxylase (fragment)Mvd1.330.02
Q6AYQ4Transmembrane protein 109Tmem1091.300.03
P0C5H9Mesencephalic astrocyte-derived neurotrophic factorManf1.290.02
P61227Ras-related protein Rap-2bRap2b1.250.03
A0A0G2JTW1Protein Rap2aRap2a1.250.04
Q66H80Coatomer subunit deltaArcn11.250.04
P63170Dynein light chain 1, cytoplasmicDynll11.240.02
B2GV08Adaptor-related protein complex 1, sigma 2 subunit (predicted), isoform CRA_aAp1s21.230.02
F1LNV5Calcium uptake protein 1, mitochondrialMicu11.220.02
Q3KRD0Aspartate-tRNA ligase, mitochondrialDars21.200.03
Q642E3CDK5 regulatory subunit associated protein 3, isoform CRA_bCdk5rap3Undetected in CUMS group/
D4A1R8Copine-1Cpne10.830.01
D3ZYT2Mitochondrial ribosomal protein S5 (predicted)Mrps50.820.01
D4AEG7Protein Tbc1d13Tbc1d130.810.02
A0A0G2K189Protein Scrn3Scrn30.810.01
Q5RK0039S ribosomal protein L46, mitochondrialMrpl460.810.01
P16975SPARCSparc0.810.02
D4A6W6Protein RGD1561333RGD15613330.800.03
F1LSW760S ribosomal protein L14Rpl140.800.01
F1LP34Acidic leucine-rich nuclear phosphoprotein 32 family member BAnp32b0.800.03
G3V8U9Proteasome subunit beta typePsmb40.790.05
P22791Hydroxymethylglutaryl-CoA synthase, mitochondrialHmgcs20.790.02
B0BN94Protein FAM136AFam136a0.760.03
D4A4Z9Protein Ktn1Ktn10.750.02
D4A2Z6Protein Sec63Sec630.740.03
G3V7J2Interferon-inducible double-stranded RNA-dependent protein kinase activator APrkra0.720.02
Q5PQZ8Selenoprotein TSelt0.700.02
A0A0G2K7G2Protein Agfg2Agfg20.660.03
M0R5T4Protein Rac3Rac30.640.02
A0A0G2K1Z2Protein Arhgap12Arhgap120.610.05
F1M0Z6NeogeninNeo10.570.04
Q6IML7DnaJ homolog subfamily C member 27Dnajc270.350.01