Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats

Figure 6

Proposed mechanism by which type 2 diabetes (T2DM) and aerobic exercise can affect the brain and lead to alterations of hippocampal glucose metabolism with subsequent effects on synaptic plasticity-associated proteins. It also suggests a mechanistic pathway by which insulin signaling, energy deficits, and inflammation can regulate hippocampal plasticity and function.