Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease

<div>Effect of MPTP and treadmill training on the brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) level in the midbrain and striatum. Immunohistochemical staining against BDNF (a) and GDNF (b) in the substantia nigra pars compacta (SNpc), quantitative analysis of BDNF and GDNF in the midbrain (c, d), and striatum (e, f). C: control; CTT: control + treadmill training; M: treatment with MPTP; METT: MPTP + early onset treadmill training; MLTT: MPTP + late-onset treadmill training group. Scale bar: 100 <i>μ</i>m. 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Neural Plasticity

fig2

Figure 2

Figure 2: Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease 