Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease

<div>Immunohistochemical staining against the glial fibrillary acid protein (GFAP) (a, d), ionized calcium binding adaptor molecule 1 (Iba1) (b, e), and integrin CD 11b (c, f) in the SNpc (a, b, c) and VTA (D, E, F). C: control; CTT: control + treadmill training; M: treatment with MPTP; METT: MPTP + early onset treadmill training; MLTT: MPTP + late-onset treadmill training group. Scale bar: 200 <i>μ</i>m (a); 400 <i>μ</i>m and 10 <i>μ</i>m (insertions) (b); 50 <i>μ</i>m and 10 <i>μ</i>m (insertions) (c); 100 <i>μ</i>m (d, f). 400 <i>μ</i>m and 100 <i>μ</i>m (insertions) (e).</div>

Neural Plasticity

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Figure 3

Figure 3: Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease 