Vasoprotective Effects of Hyperoside against Cerebral Ischemia/Reperfusion Injury in Rats: Activation of Large-Conductance Ca²⁺-Activated K⁺ Channels

Figure 9

Diagram illustrates the potential actions of Hyp on BK channels against cerebral I/R injury. Hyp appears to upregulate BK β1-subunit expression in I/R-injured VSMCs. As a result of the effects of Hyp, the oxidative stress is inhibited, resulting in increases of CBF and vasoprotection in I/R-injured rats.