Research Article
Chronic Ultrasound Prenatal Stress Altered the Brain’s Neurochemical Systems in Newborn Rats
Table 1
Correlation analysis of the relationship between the brain biochemical indicators.
| Group | Biochemical indicator 1 | Biochemical indicator 2 | R | p Value |
| Brain regions—hippocampus and frontal cortex (neurotransmitter systems) |
| Control offspring | Dopamine (FC) | DOPAC (FC) | 0.61 | 0.005 | DOPAC/dopamine ratio (FC) | Dopamine (FC) | −0.57 | 0.0096 | HIAA/serotonin ratio (FC) | HIAA (FC) | 0.86 | <0.001 | DOPAC/dopamine ratio (H) | Dopamine (H) | −0.82 | 0.002 | HIAA/serotonin ratio (H) | Norepinephrine (H) | −0.58 | 0.008 | HIAA/serotonin ratio (H) | HIAA (H) | 0.59 | 0.007 | HIAA/serotonin ratio (H) | Serotonin (H) | −0.64 | 0.003 |
| PS offspring | DOPAC (FC) | Norepinephrine (FC) | 0.60 | 0.008 | Dopamine (FC) | DOPAC (FC) | 0.70 | 0.001 | Serotonin (FC) | HIAA (FC) | 0.81 | <0.001 | Dopamine (H) | HIAA/serotonin ratio (FC) | 0.67 | 0.007 | Dopamine (H) | DOPAC (H) | 0.81 | <0.001 | DOPAC/dopamine ratio (H) | HIAA (FC) | −0.66 | 0.009 | DOPAC/dopamine ratio (H) | Dopamine (H) | −0.82 | <0.001 | HIAA (H) | HIAA/serotonin ratio (FC) | 0.90 | <0.001 | HIAA (H) | DOPAC (H) | 0.70 | 0.005 | HIAA (H) | Dopamine (H) | 0.80 | <0.001 | Serotonin (H) | Dopamine (H) | 0.72 | 0.003 | Serotonin (H) | HIAA (H) | 0.68 | 0.001 | HIAA/serotonin ratio (H) | HIAA/serotonin ratio (FC) | 0.67 | 0.002 | HIAA/serotonin ratio (H) | HIAA (H) | 0.63 | 0.004 |
| Control males | HIAA/serotonin ratio (FC) | HIAA (FC) | 0.85 | 0.003 |
| Control females | HIAA/serotonin ratio (FC) | HIAA (FC) | 0.91 | <0.001 | HIAA (H) | HIAA (FC) | 0.82 | 0.007 |
| PS males | HIAA/serotonin ratio (FC) | DOPAC (FC) | −0.83 | 0.008 | Serotonin (FC) | HIAA (FC) | 0.83 | 0.006 | Dopamine (H) | DOPAC (H) | 0.92 | 0.001 | HIAA (H) | HIAA/serotonin ratio (FC) | 0.90 | <0.001 | HIAA (H) | DOPAC (H) | 0.83 | 0.008 |
| PS females | HIAA (H) | HIAA/serotonin ratio (FC) | 0.90 | <0.001 |
| Whole brain (BDNF and neuropeptides) |
| Control offspring | Oxytocin | BDNF | 0.72 | <0.001 | Oxytocin | α-MSH | 0.62 | 0.005 | Oxytocin | β-Endorphin | 0.71 | <0.001 | Neurotensin | α-MSH | 0.80 | <0.001 |
| PS offspring | β-Endorphin | α-MSH | 0.70 | <0.001 | Substance P | Neurotensin | 0.82 | <0.001 |
| Control males | Neurotensin | α-MSH | 0.81 | 0.008 |
| PS males | Substance P | Neurotensin | 0.83 | 0.006 |
| PS females | β-Endorphin | α-MSH | 0.82 | 0.007 | Substance P | Neurotensin | 0.85 | 0.003 |
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α-MSH, α-melanocyte-stimulating hormone; BDNF, brain-derived neurotrophic factor; DOPAC, 3,4-dihydroxyphenylacetic acid; H, hippocampus; HIAA, 5-hydroxyindoleacetic acid; PS, prenatal stress; FC, frontal cortex.
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