The central nervous system is a highly plastic structure that can adapt throughout the lifespan of an animal to changes in environment. The establishment of neural connectivity, during embryonic period and during early postnatal stages, is under genetic and epigenetic control. Environmental factors, in particular during the critical period, can heavily influence the organization of the brain, in the long term. In the 1980s, Kaas, Merzenich, and collaborators have reported that the adult central nervous system of mammals was also capable of a remarkable reorganization following traumatic lesions (amputation, nerve section, etc.). Since these pioneering works, the concept of neural plasticity stirs up a growing interest in the scientific community. Many works have been focused on the remodeling of cortical and subcortical structures in relation to individual experience. In particular, it has been demonstrated that the topographic maps in both somatosensory and motor adult cortices are idiosyncratic; they are dynamically reorganized to respond to behavioral context and challenges.

A better knowledge of neural plasticity is mandatory to develop efficient rehabilitation strategies or to promote a successful aging. Thus, it appears important to gain new insights into the underlying mechanisms of neural plasticity that occurs in response to changes in sensorimotor experience.

Original research articles are appreciated as well as reviews, which would bring a better knowledge in sensorimotor plasticity in response to nontraumatic situations (disuse or overuse, aging, muscular disorders, focal dystonia, etc.) from the molecular to the behavioral level. Potential topics include, but are not limited to:

• Biochemical and morphological mechanisms
• Functional relevance of sensorimotor plasticity
• Countermeasures or therapy to promote plasticity
• Rehabilitation strategies
• Glial-neuronal interaction

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