CNS Plasticity in Injury and Disease
1Emory University, Atlanta, USA
2University of Kentucky, Lexington, USA
3University of California, San Francisco, USA
CNS Plasticity in Injury and Disease
Description
The central nervous system (CNS) undergoes many changes in trauma and disease, not all deleterious. The prior dogmatic belief that regeneration does not occur in the adult CNS has been disproven. Both neurons and oligodendrocytes undergo organized apoptotic cell death after CNS injury, and both cell types have the capacity to undergo some measure of regeneration after injury.
In fact, the microenvironment of the injured CNS may be especially supportive of plasticity due to inflammation and release of trophic factors. Reparative and compensatory events may occur at several levels including synaptic changes, neuronal and glial regeneration, and development of compensatory systems.
We invite investigators to contribute original research as well as review articles that examine plasticity in the CNS after injury and in disease.
Potential topics include, but are not limited to:
- Neurogenesis after CNS trauma
- Regeneration in CNS disease
- Synaptic changes in trauma and disease
- Neuronal and glial death and regeneration after injury
- Stem cell biology in the injured nervous system
- Therapies for enhancing CNS plasticity after injury
- Effects of neuroinflammation on CNS plasticity
- Clinical evidence for plasticity after CNS injury