Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis

Figure 2

Proposed role of Tregitopes in IgG. Adapted with permission from de Groot et al. [18]. Antibody-derived Treg epitope (dark blue) activated regulatory T cells (Treg), which leads to suppression of effector T cells (Teff) that recognize effector epitope (red), like those of IgG hypervariable regions to which central tolerance does not exist.