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Neurology Research International
Volume 2011 (2011), Article ID 563784, 7 pages
http://dx.doi.org/10.1155/2011/563784
Review Article

Huntington's Disease: An Immune Perspective

1Centre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UK
2Centre of Biotechnology and Bioinformatics, School of Life Sciences, Jawaharlal Nehru Institute for Advanced Study, Secunderabad, Andhra Pradesh, India
3Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
4Unit of Neurology, Department of Neurological Disorders, Santa Chiara Hospital, Largo Medaglie d'oro 1, 38100 Trento, Italy

Received 17 November 2010; Revised 31 March 2011; Accepted 12 May 2011

Academic Editor: Mohammed Rachidi

Copyright © 2011 Annapurna Nayak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.