Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research
Figure 1
White matter damage in the human preterm brain is characterized by microscopic foci of necrosis and diffuse reactive gliosis, microglial activation, and axonal damage. (a) Camera lucida drawing of the distribution of microcysts (*) and axonal fragments (arrows) in the posterior frontal white matter (level of the body of the corpus callosum [CC]). In the white matter distant from periventricular foci of necrosis is reactive gliosis, as demonstrated by the immunomarker glial fibrillary acidic protein (b), microglial activation, as demonstrated by the immunomarker CD68 (c), and axonal injury, as demonstrated by the immunomarker fraction (d).
