Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research
Table 1
Key developmental events in the cerebral white matter, cortex, and subplate region in the last half of human gestation for considering in the design of animal models of the encephalopathy of prematurity.
(1) Cerebral white matter
(a) Development of vasculature and autoregulation
(b) Dominance of pre-OLs
(c) Overexpression of pre-OLs of calcium-permeable, GluR2-deficient AMPA receptors
(d) Expression of pre-OLs of NDMA receptors
(e) Transient expression of glutamate transporter EAAT2
(f) Transient abundance of microglia
(g) Oligodendrocyte expression of cytokine (interferon-γ) receptors
(h) Radial glial fiber transformation and disappearance
(i) Late formation of fibrous astrocytes
(j) Lag in the expression of superoxide dismutases
(k) Active axonal elongation
(2) Cerebral cortex
(a) Gyration
(b) Lamination
(c) Neuronal differentiation
(d) Late migration of GABAergic neurons
(e) Late formation of protoplasmic astrocytes following neuronal migration
